The EMBO Journal5d
Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration
Cells navigating in complex microenvironments frequently encounter narrow spaces that physically challenge migration.
The EMBO Journal6d
Type-2 innate signals are dispensable for skeletal muscle regeneration and pathology linked to Duchenne muscular dystrophy
Contrary to prior data, this study shows that neither eosinophils nor STAT6-mediated IL-4/IL-13 signaling contribute ...
The EMBO Journal9d
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...
The EMBO Journal13d
Boosting human immunology: harnessing the potential of immune organoids
Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...
The EMBO Journal3d
Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common cause of liver cirrhosis, ...
The EMBO Journal2d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Glioblastoma is one of the most treatment-resistant and lethal cancers, with a subset of self-renewing brain tumour stem cells (BTSCs), driving therapy resistance and relapse. Here, we report that ...
The EMBO Journal3d
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Monoallelic loss of PTEN and ARID1A is ...
The EMBO Journal3d
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. One way cells control the speed and ...
The EMBO Journal12d
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ferroptosis, an iron-dependent form of ...