The EMBO Journal2d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Glioblastoma is one of the most treatment-resistant and lethal cancers, with a subset of self-renewing brain tumour stem cells (BTSCs), driving therapy resistance and relapse. Here, we report that ...
The EMBO Journal3d
Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common cause of liver cirrhosis, ...
The EMBO Journal3d
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Monoallelic loss of PTEN and ARID1A is ...
The EMBO Journal3d
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. One way cells control the speed and ...
The EMBO Journal3d
Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells navigating in complex 3D ...
The EMBO Journal4d
HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The SCF (SKP1/CUL1/F-box protein) ubiquitin ...