Lupus Science & Medicine® is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. An official journal of the Lupus Foundation of America (LFA), which is dedicated to advancing the science and medicine of lupus while offering support to ...

A lupus journal publishing basic, clinical, translational and epidemiological studies on all aspects of lupus and related diseases. An official journal of Lupus Foundation of America.

The paradigm of drug approval in SLE currently relies on successful large phase III randomised controlled trials and a set of primary, secondary and additional end points. Taken together, these outcomes offer a nuanced understanding of the efficacy and safety of the investigational agent. In this review, we thoroughly examine the main outcomes used in SLE trials and highlight unmet ...

Rendas-aumR et−al Lupus Science Medicine 22411e111 doi11136lupus-223-111 1 SF-36v2 and FACIT-Fatigue quality of life improvements with organ-specific SELENA-SLEDAI response and belimumab treatment in patients with

Sep 4, 2024 · Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 Differentiating lupus flare from HLH can be challenging, since both can cause fever and cytopenia. A recent review of published literature included studies that combined information about a total ...

Sep 27, 2022 · Purpose Activation of toll-like receptor (TLR)7/8 by self-RNA induces production of type I interferon and several other proinflammatory cytokines, which may contribute to the pathophysiology of SLE and other related autoimmune diseases. Afimetoran, a potent, selective, oral small-molecule inhibitor of TLR7/8, was developed for potential treatment of autoimmune diseases and has shown robust ...

Lupus Science & Medicine® is a global, peer reviewed, open access, online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. Research on lupus will be considered from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology ...

AdelhelmfiBH, etfial Lupus Science Medicine 202310e001018 doi101136lupus2023001018 1 Therapy with direct oral anticoagulants for secondary prevention of thromboembolic events in the antiphospholipid syndrome: a systematic review and meta-analysis of

Feb 7, 2019 · Unmet needs in the management of SLE. Significant advances accomplished over the past decades in the treatment of SLE have resulted in increased patient survival and reduced rates of end-stage renal disease in cases with kidney involvement.1 2 Nevertheless, management of patients with lupus still remains far from optimal, complete control of disease activity is only infrequently obtained,3–5 ...

Lufi, et≥al Lupus Science Medicine 20229e000718 doi101136/lupus-2022-000718 1 Utility of the ACR- 1997, SLICC-2012 and EULAR/ACR-­2019­classification­criteria­ for­systemic­lupus­erythematosus:­a­ single-­centre­retrospective­study